This clinical study provides a rationale for the utility of raf and mek inhibitors in combination with shp2 inhibitors in overcoming resistance to targeted therapies, presenting a. By transcriptomic analysis, lubrano et al. In this review, the significant role of the mapk pathway in carcinogenesis and its therapeutic potential are comprehensively examined with a focus on mek inhibitors.
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The ras/raf/mek/erk (mapk) pathway plays a role in ovarian carcinogenesis. Abstract cancer cells often adapt to targeted therapies, yet the molecular mechanisms underlying adaptive resistance remain only partially understood.
